GLP-1 receptor agonist (GLP-1 RAS), a drug that helps regulate it Type 2 diabetes And while obesity can have a big impact on your physical health, what about mental health?
Some examples of these drugs include semaglutides such as Ozempic and Wegovi, and liraglutides such as Viktuza and Saxenda.
Various studies have pointed out that it causes GLP-1 RAS Mental health complicationsanxiety and depression, etc.
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In June 2024, the National Institutes of Health (NIH) published a study that considered the correlation between semaglutide therapy and “advancing mood disorders.”
This study highlighted the association between negative mood changes in type 2 diabetes patients. History of depressionwarning healthcare providers to recognize this “potential risk.”
The study discusses the correlation between GLP-1 RA drugs and mood changes. (istock)
But more than that Recent researchpublished in the journal Diabetes, Obesity and Metabolism, suggested that these mood changes are related to genetic variation in diverse populations and ancestors within the UK biobank.
Although the GLP-1 RA variant had a “consistent cardiovascular metabolic effect” across all groups, the researchers stated that the negative effects on mental health were “more diverse” and concluded that behavioral changes “maybe more likely to not act directly.” [the medications]. ”
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Doctors measure medicine and mood
Dr. Brett Osborne, a Florida neurosurgeon who often prescribes GLP-1 RAS to patients, believes there is no “consistent causal relationship” between these medications and mental illness.
“The researchers have assayed genetic markers in almost half a million people from various backgrounds in search of a link between the genes behind the GLP-1 receptor and mental health issues. Depression, anxiety Or suicidal ideation – and they couldn’t find it,” he summoned.
Patients and physicians report that GLP-1 receptor agonists are associated with mood changes. (istock)
people Who is obese? Or, the type 2 diabetes fight is “often already depressed” without drugs, doctors pointed out.
“These conditions are physically, emotionally and socially sacrificed,” he said. “So, yes, the majority of patients starting GLP-1 drugs are already dealing with mental health struggles. But it’s not because of the drugs, it’s because of the illness.”
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As these individuals begin to lose weight, their blood sugar levels stabilize, their energy improves, and their moods usually improves.
“GLP-1 drugs help people get back to their health,” Osborne noted. “They reduce inflammation. They lower blood sugar levels. They Reduce the waistline. ”
“And when people seem to look better, when their bodies start working for them rather than ultimately oppose them, they often are less, not less.”
“GLP-1 drugs help people get back to their health,” said one doctor. “And when people seem to look better, when their bodies start working for them rather than ultimately oppose them, they often are less, not less.” (istock)
Dr. Muhammad Ganem, a Obesity surgeon The Orlando Health Weight Loss and Bariatric Surgery Institute shared in another interview with Fox News Digital. Some of his patients report mood changes, while others “have none at all.”
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“Depression and mood changes are very common, especially today. [determine] “Is this related to GLP-1 agonist drugs, or did I just happen to start suffering from these after I started using them,” he said.
“It’s really hard to know if it’s a change in personality that can occur due to weight loss or a side effect due to a change in mood,” he added. “I don’t think there’s enough data yet to reach that conclusion.”
For those interested in GLP-1 RA medications or experiencing changes in mood, experts emphasized the importance of intimate contact with healthcare providers. (istock)
Patients who lose weight with GLP-1 RA confidently experience a “big boost” and experience a change in personality. Even the relationshipaccording to Ganem.
“It really depends on the people and the support system they have,” he said. “To reach a conclusion, we need appropriate randomized controlled trials and better studies to determine whether this is related to the drug itself or simply to weight loss.”
“It is important for all physicians who prescribe these medications to recognize and confirm the patient’s history.”
For those interested in these medications or those experiencing changes in mood, the surgeon emphasized the importance of intimate contact. Healthcare provider.
“Like any other drug, they can have potential side effects,” he said.
Ganem recommended looking for professionals and practices that would adopt a “holistic approach” to weight loss, providing mental health support in addition to medication.
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“Obesity is complicated,” Dr. Brunilda Nazario, chief physician editor at WebMD’s Medical Office, told Fox News Digital.
“Obesity experts are … cautiously excited about how well these medications work,” she said.
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“In the current study showing conflicting results regarding mood disorders and GLP-1 drug use, it is important for all physicians who prescribe these drugs to check and confirm the patient’s history before prescribing. [them]. ”
“Don’t be afraid to ask for help if something feels incorrect. Your health depends on it,” one expert suggested. (istock)
Nazario emphasized that it is “important” for GLP-1 RA users to listen to their bodies, urging them to pay attention to their mood and to know about symptoms of mood disorders.
“Don’t be afraid to ask for help even if something feels incorrect — Your health It depends on that,” he added.
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Nazario pointed out that GLP-1 Ras can affect mood in a variety of ways.
“They’re not all negative, they can also improve their mood,” she said. “Just seeing great results can help you improve your self-esteem, confidence and physical image.”
