Many factors lead to an irritating cycle of weight gain and weight loss, but the driving force can be fat cells Memory of obesity.
That’s according to a recent study first published in the Nature Journal Nature last fall.
Researchers say that fat cells can be more likely to regain weight after pounds have fallen into abnormal metabolic pathways in the body.
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A team of Swiss scientists was interested Regaining weight After becoming slimmer, it is due to “metabolic memory,” and the body is striving to return to its previous obesity state.
Many factors lead to an irritating cycle of weight gain and weight loss, but the driving force can be fat cells that retain obesity memories. (istock)
They analyzed chemical markers of fat cells in mice fed a high-fat diet. Next, when mice were fed only standard diets, the researchers analyzed the adipose tissue after losing weight, according to the study article.
The team then compared these samples to the fed lean mouse group. Standard meal Check if chemical markers in adipocytes are associated with unhealthy changes in the body.
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High-fat diet mice continued to produce unhealthy changes in metabolism after losing weight, including more difficulties in regulating sugar metabolism, inflammation, and abnormal fat storage.
Previously obese mice weighed faster than controls after eating a high-fat diet. Lose weighta researcher discovered.
Previously obese mice weighed faster than controls after eating a high-fat diet. This suggests a continuous impairment of metabolism after weight loss. (istock)
This study also examined a human sample analyzing how fat cell genes can lead to unhealthy changes in the body, like mice.
The researchers analyzed participants’ adipose tissue before and after undergoing bariatric surgery and compared it with fat cells from lean people who had no history of obesity.
“This recent study suggests that after someone loses weight, their fat cells don’t return to completely “normal.” ”
In obese individuals, the adipocyte genes continued to function abnormally in the body, increasing inflammation and metabolism problems two years after losing weight.
One limitation of this study is that we only saw one type of cell, i.e. adipocytes. Further research is needed to determine whether other cells or tissues in the body also retain overweight memories, the researchers acknowledged.
A “complex mix” of factors
Fat cells certainly have a memory of being obese, allowing them to regain weight and remain in a state that promotes inflammation and metabolism problems. (She was not part of the research.)
“This recent study suggests that after someone loses weight, their fat cells won’t return to completely “normal,” Zimmermann told Fox News Digital.
The researchers analyzed participants’ adipose tissue before and after undergoing bariatric surgery and compared it with fat cells from lean people who had no history of obesity. (istock)
But biology plays an important role in obesity, but that’s not all, she warned.
““The complex combination of genetics, biology, environment, psychology, pharmacologies and social determinants all form obesity,” Zimmermann said.
“Keep moving, eat real food, build muscle.”
Healthy habits can counteract genetics that promote weight gain.
Ideally, experts said, this involves getting a combination of Physical Activities (including strength training), Zimmermann says there is sufficient protein and fiber from plants to combat oxidative stress and chronic inflammation, as well as phytonutrients.
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“Keeping on, eating real food, building muscle,” she said.
“These behaviors reduce inflammation, improve glycemic control, contribute to a healthy microbiota, and protect metabolism.
Healthy habits can counteract genetics that promote weight gain, researchers say. (istock)
However, for some people, there may be some underlying problems. I’ll lie down Epigeneticsaccording to the Centers for Disease Control and Prevention, involves how a person’s behavior and surrounding environment affect how genes function in the body.
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“Obesity is a chronic recurrence condition with an epigenetic cause,” Dr. Caroline Apobian, professor of medicine at Harvard Medical School and co-director of the Weight Management and Wellness Center at Brigham and Women’s Hospital, told Fox News Digital.
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People who tend to store calories can have difficulty losing weight Diet and exercisecompared to those who have a simpler time, according to Apobian, who was not involved in the study.
Fox News Digital has requested the study authors for comment.
