Sperm from a single donor in Europe is Imagine at least 67 pregnancyAlthough the donor carried mutations that cause rare cancers.
According to a report by the Guardian, donor mutations are associated with cancer diagnosis in 10 of these children.
The incident was revealed after two families contacted their fertility clinic separately after them Pediatric cancer diagnosis It was linked to a rare genetic variant called TP53.
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Mutations in the TP53 gene cause Li-plasma syndrome and increase the risk of Cancer outbreak. Cleveland Clinic says the disorder has a 90% chance of developing some type of cancer by the age of 60 and a 50% chance of developing the disorder by the age of 40.
Sperm supplier European Sperm Bank confirmed that this variant is present in some of the donor’s sperm.
Researcher Dr. Edwige Kasper (not photographed) advocates for European restrictions on the number of births or families of a single donor. (istock)
The Guardian reported that the rare variant was “not known to be cancer-related at the time of its donation in 2008.”
Genetic mutations reportedly could not be detected by standard screening, and donors are said to be in healthy now.
“The identified mutations are mutations that were not detected by the screening methods used in accordance with regulations.”
Dr. Edwige Casper, a biologist at the University Hospital of Louen in France, presented the incident at the annual meeting of the European Association of Human Genetics in Milan last week, commenting on the need for European restrictions. Birth count Or a family for a single donor.
“You can’t do whole genome sequencing for every sperm donor. I’m not arguing for that,” she told the Guardian. “But this is an abnormal spread of genetic diseases. Not everyone has 75 children in Europe.”
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Kasper analyzed the mutation in her lab and concluded that it was probably the cause of cancer and that the child born from this donor should “receive genetic counseling.”
The research-turned-invest followed 67 children from 46 families in eight European countries. The kids were testedof which 23 variants were detected.
Ten people diagnosed with cancer reportedly included cases of leukemia and non-Hodgkin’s lymphoma.
Sixty-seven children from 46 families were identified by donors from eight European countries. (istock)
In a statement sent to Fox News Digital, the European sperm bank said donor-assisted reproduction “generally remains a safer alternative.” Genetic Screening.
The bank added that sperm donors are undergoing “comprehensive health screenings.” This includes detailed health checks, reviews of the donor’s family history, and genetic and “extensive” tests. Infectious diseases.
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“However, it is not possible to rule out all risks. In this particular case, the identified mutations are not detectable by the screening methods used in accordance with regulations and require specialized genetic testing,” the group said.
Julie Pauli Buddts, VP. Among the corporate communications at the European Sperm Bank, he announced to Fox News Digital that he was deeply influenced by this case.
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“Donors are thoroughly tested beyond the required standards, but preventive genetic screening is now at its limit,” she said.
“Every human has around 20,000 genes, and if you don’t know what you’re looking for, it’s simply impossible to detect a disease-causing mutation in a person’s gene pool.”
Eggs and sperm are stored in liquid nitrogen tanks at the Fertility Center Berlin. (Photo Alliance by Jens Carreen/Getty Images)
Budtz noted that European sperm banks welcome “continued dialogue” about setting “international binding family restrictions.”
“This is also the reason, in addition to being nationally compliant. Pregnancy restrictionsactively implemented its own international restrictions for 75 families per donor,” she added.
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In the US there are no official legal restrictions on how many sperm a man can donate.
However, the American Association of Reproductive Medicine (ASRM) recommends that donors be limited to 25 births within each population area of 800,000 people.
“Institutions, clinics and sperm banks need to maintain adequate records to set limits. Number of pregnancy Certain donors are responsible,” ASRM said on its website.
“Limiting donor vials is an important part of the process.”
California Clybank, which claims to have the largest selection of sperm and egg donations in the country, says on its website it will monitor donors and limit the total number of family units to 20-30 worldwide.
“Limiting donor vials is an important part of the process,” the bank noted.
The Federal Drug Administration requires that all sperm donors undergo physical examinations, complete a survey, provide medical history, and be screened for infectious diseases in an FDA-approved lab. (istock)
The Federal Drug Administration (FDA) requires that all sperm donors undergo physical examinations, complete a survey, provide medical history, and be screened for infectious diseases in an FDA-approved lab.
Additionally, ASRM suggests that donors will undergo psychological and genetic screening, and also recommends infectious disease testing for recipients and recipients. Sexually intimate partneraccording to its website.
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“Legal consultations and laws may vary from state to state,” the organization notes.
California cryobank requires donors to be tested for infectious diseases, undergo genetic screening, psychological assessments, criminal history checks, and screened. Zika virusaccording to the bank’s website.
