Common artificial sweeteners can be made Cancer treatment Because of its low effect, new research has been discovered.
Sucralose, a sweetener found in many diet sodas, low-calorie snacks and powdered sugar substitutes, can interfere with immunotherapy in cancer patients, according to a study from the University of Pittsburgh and the UPMC Hillman Cancer Center.
This study included 132 patients with melanoma (fatal morphology of the morphology of Skin cancerand non-small cell lung cancer (the most common type of lung cancer).
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All patients were taking anti-PD1 (a type of immunotherapy) alone or in combination with chemotherapy.
They are all Artificial sweeteners They consumed.
Researchers found that patients who consumed high levels of sucralose had “worst responses” with immunotherapy.Low survival rate“According to the press release, it’s more than people who consumed small amounts.
“We’ve seen a lot of people who have had a lot of trouble with their health,” said Diwakar Daval, Associate Professor of Medicine at Pitt and a medical oncologist and hematologist at UPMC Hillman Cancer Center.
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“These observations increase the likelihood of designing targeted prebiotics. Nutritional supplement For patients who consume high levels of sucralose. ”
The findings were published in Cancer Discovery, a journal by the Cancer Research Association.
In positive note, researchers also defeated their effects by taking supplements to increase the levels of the amino acid arginine, Effectiveness of immunotherapyas seen in mouse studies.
“It’s easy to say” Stop drinking Diet Soda‘But when patients are being treated for cancer, it may not be realistic to ask them to dramatically change their diet because they are already dealing with it well,” said lead author Abby Overacer, an assistant professor at the Department of Immunology at Pitt and UPMC Hillman Cancer Center in the release.
“We need to meet patients with patients, which is why arginine supplementation could be a simple approach to combating the negative effects of sucralose on immunotherapy.”
A study of mice showed that sucralose is altered Intestinal microbiota A method to reduce arginine levels. This amino acid is essential for T-cell function, an important component of immunotherapeutic drugs.
“If arginine levels were depleted due to the sucralose-driven shift of the microbiome, T cells were not able to function properly,” Oberare said. “As a result, immunotherapy was not as effective in mice fed sucralose.”
Researchers plan to launch a Clinical trials A survey of arginine supplementation in human cancer patients. We also explore the potential impact of other sugar alternatives on the effectiveness of immunotherapy.
This study was supported by the National Institutes of Health, the Damon Lannion Cancer Research Foundation, and the Gateway for Cancer Research.
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Calorie Control Council has provided the following statement to Fox News Digital:
“For those undergoing cancer treatment, all guidance should come from them Healthcare Team” said Council president Carla Sanders.
“This study has some limitations and relies on research into animals that cannot be applied directly to humans. [is] Small observational studies of humans using self-reports Food dataoften subject to false reporting, underreporting and bias. While continuous research is important, scientific regulators around the world, including the FDA, have repeatedly confirmed the safety of sucralose for decades. ”
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Fox News Digital reached out to manufacturers of products that include sucralose, requesting comment.
