Common over-the-counter drugs can significantly reduce the risk of Colorectal cancer I’ll be back.
A Swedish study showed that low doses of aspirin recur in half for patients with colon and rectal cancer whose tumors have certain types of genetic mutations.
Researchers at Karolinska Institetet and Karolinska University Hospital have followed more than 3,500 cancer patients from 33 hospitals in Sweden, Norway, Denmark and Finland, according to a press release. All patients had Had surgery Remove the tumor.
Long distance running linked to high risk of colon cancer, early studies suggest
Of those carrying a specific genetic mutation in the PIK3 signaling pathway, half received 160 milligrams of aspirin daily, and the other half received a placebo.
Three years later, Risk of cancer recurrence Who’s reduced by 55% I took aspirin Compared to the placebo group.
“For the first time in a randomized setting, the ALASCCA trial shows that low-dose aspirin significantly reduces recurrence in colorectal cancer patients with altered somatic PI3K pathways,” study authors Anna Martyling, MD, PhD, Molecular Medical and Surgery, senior consultant Surgeon Consultant Surgenka Institet at Karolinska University, Molecular Medical and Surgery
Research into reducing risks of colon cancer by eating certain types of vegetables
“This applies to more than a third of all patients with resected colorectal cancer.”
The effect was Women are strongerAccording to Martling, this guarantees further investigation.
The findings were published in the New England Journal of Medicine.
Aspirin is a drug that is readily available worldwide compared to many modern times. Cancer drugsMartling pointed out.
Aspirin, which is intended to relieve pain, fever and inflammation, is a non-steroidal anti-inflammatory drug (NSAID). Low-dose medications are also used to prevent blood clots.
This study confirms what previous observational studies suggested, this time in a randomised study.
Dr. Mark Siegel, senior medical analyst at Fox News, was not the case. I’m involved in research However, he shared his reaction in an interview with Fox News Digital.
“Aspirin is an anti-inflammatory agent and is involved in reducing growth factors,” he said. “Many studies have shown that regular use of NSAIDs reduces the risk of developing and mortality from colon cancer.”
Colorectal cancer can cause these four hidden warning signs, experts say
The PIK3CA mutation in this study leads to rapid cell proliferation of cancer, seen in 55% of breast cancer and around 30% of colon cancer, Siegel noted.
“This large-scale randomized Scandinavian study reveals a 50% reduction in recurrence in people with colon cancer and PIK3 mutations,” he repeatedly added. More research You need to do it.
The study had several limitations, the authors acknowledged. “Like other trials, there is a warning. The study was not powered for a detailed subgroup analysis and did not include patients over 80,” Martling said.
“Longer follow-up is also needed to see the impact on overall survival.”
Some common side effects of aspirin include Stomach problems Researchers say increased bleeding tendency. Do not use by people with stomach ulcers, bleeding disorders or asthma.
Experts advise that people who use other blood thinners or alcohol should use aspirin carefully.
Despite the limitations, researchers believe the results are “quickly relevant” to clinicians and guidelines committees.
Click here to sign up for our health newsletter
“In postoperative colorectal cancer patients, testing for changes in the PI3K pathway should be considered,” Martling recommended. “However, for patients, guidelines and Doctor’s Treatment We will adopt these findings. ”
The test, according to researchers, is a powerful example of “precision drugs.” High-tech platform Meet famous low-cost drugs.
“If widely implemented, regimens can prevent thousands of recurrences each year, and save lives each year, especially in environments where access to expensive new drugs is limited,” she added.
Visit us for more health articles www.foxnews.com/health
When asked if regular aspirin should be administered to all people who have experienced colon cancer, Siegel said it should be used more commonly than before, but doctors said it should be analyzed Risks and Benefits Use of aspirin on a case-by-case basis.
This study was funded in part by the Swedish Research Council and the Swedish Cancer Society.
