At the age of 117, Maria Blañas was confirmed by the Guinness World Records as the oldest living person in the world. Long life It wasn’t just good fortune.
In a statement to Guinness, Blañas attributed her longevity to “order, tranquility and good connections.” Family and friendscontact with nature, emotional stability, no worries, regret, lots of positivity, and away from toxic people. ”
Before her death on August 19, 2024, scientists at the Josep Carreras Institute in Barcelona, Spain studied Brannas genetic samples to confirm the reasons for her longevity.
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According to a press release, the research team is led by Dr. Manel Esteller, head of the Cancer Epigenetics Group at the Josep Carreras Leukemia Research Institute, and the team used a non-invasive method to sample three different tissues.
They analyzed Branyas genome (DNA sequencing), epigenome (DNA methylation), transcriptome (gene expression at the RNA level), proteome (gene expression at the protein level), and metabolism (small molecules such as cholesterol and sugar).
The team detected signs of aging in their analysis, but Branyas also found that there are genetic properties associated with neuroprotection. and cardiac protection“Low levels of inflammation.”
“Branyas had an exceptional genome enriched in gene variants associated with enhancing lifespans in other species (dogs, insects, flies, etc.) and genes that provided cardiac lipid protection and cardiac protection. Retention of cognition” Esterer told Fox News Digital.
“At the same time, she had no associated genetic mutants. [with] Risk of pathology Cancer etc.Alzheimer’s disease and metabolic disorders. ”
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There were also a lot of them in Blañas. Beneficial bacteria Bifidobacterium in her microbiome (intestine). Researchers have chalked up to frequent consumption of yogurt.
Bifidobacterium helps boost the immune system, balance inflammation, regulate metabolism, and digest certain carbohydrates and dietary fiber.
“We explained to her that yogurt consumption and the composition of bacteria in her intestines could be linked to her long lifespan,” Esterer said.
“And her lipid profile was amazing. It was followed by very low cholesterol, low LDL (bad fat), and high HDL (good fat),” he continued. “This was related to her A simple meal And the genes that quickly metabolize damaged molecules. ”
Blañas also did not smoke or drink alcohol.
Researchers say that her age is younger than her, as determined by epigenetic markers.
This study, published in the Journal Cell Reports Medicine, is Supercenter Biology (People for over 110 years), according to Esteller.
He called Blagna “an exceptional person, the smile that illuminated the room and the optimism we deeply needed” and “want to help others” by participating in further research.
According to Guinness, Blañas had no health issues, but she was hearing difficult and had some mobility issues, and her mind was “completely clear.”
Overall, the fact that she lived in 117 without serious illness suggests that aging can be “clearly distinguished from illness,” the researchers write.
The team concluded.Healthy eatingan exciting and diverse social network, and a lack of toxic habits, “probably played a role in Branyas,” and “exceptional longevity.”
Blañas also told Guinness, “I think longevity can be lucky. Luck and good genetics.”
In their study, researchers identified the following factors that could be raised: Healthy aging According to Esteller, it expanded the longevity of the Branyas.
According to Esteller, the biggest takeaway from this study is that it is likely to identify and achieve healthy aging markers Quite a long life.
“For example, her very short telomeres showed that these cells were split multiple times, but that didn’t affect her well-being,” he said. “Rejuvenating microbiomes and epigenomes provided a positive effect on extreme lifespans.”
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The study also suggests that dietary changes can help avoid obesity and other related diseases, but can also improve their lifespan. Intestinal health.
“Finally, the identification of genes associated with hypercentral features may provide new targets for pharmacological development, opening the door to more “intelligent” drugs and increasing healthy lifespan,” Esterer said.
The study had some limitations, and researchers included the fact that aging was a “highly personalized process” shaped by many people. Genetic and environmental factors.
“It should be taken with caution to draw widely applicable conclusions from a single subject,” they wrote, noting that a more detailed study of aging features is necessary.
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“The ultimate limitation of our work is that we haven’t studied The impact of exercise Or, we evaluated the effects of drugs targeting metabolic modulation or some of the observed characteristics to investigate potential anti-aging effects,” the researchers added.
