Shortly after President Donald Trump’s announcement of Monday’s executive order Prescription drug price In the US, the spotlight is about current costs and how much money Americans can save.
The president’s order calls for “drug pricing in the most preferred countries.” This means “the lowest price paid for drugs in other developed countries, or the price paid by Americans.”
“Prices for some prescription drugs and medicines will be reduced by almost 50-80-90%,” Trump said.
President Trump will take on “Big Pharma” by signing an executive order to lower drug prices
Katy Dubinsky, a New York pharmacist and founder and CEO of Vitalize, praised the move to lower prescription prices. Trump’s Order Tackling long-standing issues.
“But this isn’t easy to achieve,” she told Fox News Digital.
Following the announcement of President Trump’s executive order to cut prescription drug prices in the United States, the spotlight is about current costs and how much Americans can save. (istock)
“The executive order doesn’t cut costs anytime soon,” she said. “We’re telling the agency to begin drafting rules, which can take several months.”
Here are five of the most expensive prescription drugs in the US at a price.
5 of the most expensive prescription drugs in the US
Dubinsky today detailed some of the most expensive prescription drugs in the country and what conditions they treat.
1. Atidarsagene autotemcel by Orchard Therapeutics – $4.25 million
This drug is used to treat metachromatic leukemia (MLD). this is, Nervous systemsaid Dubinsky.
“It’s given once and is supposed to stop or slow down the illness of a young child,” she pointed out.
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2. Hemgenix by CSL Bering (Etranacogen dezaparvovec-drlb) – $3.5 million
This medication is prescribed in people with hemophilia B, a hemorrhagic disorder.
“This one-off treatment helps the body create its own coagulation factors, so patients do not need regular injections,” Dubinsky said.
3. Elevidys (Delandistrogene Moxeparvovec-Rokl) by Sarepta Therapeutics – $3.2 million
This prescription drug is intended Young boyTreat Duchenne muscular dystrophy (DMD). This is a condition in which the muscles weaken over time.
“We aim to slow the speed at which the disease progresses,” Dubinski said.

The president’s order calls for “drug pricing in the most preferred countries.” This means “the lowest price paid for drugs in other developed countries, or the price paid by Americans.” (istock)
4. Skysona (Elivaldogene autotemcel) by BluebirdBio – $3 million
“This drug is used for adrenal dermatosis (CALD). Brain disease In boys, “This therapy attempts to delay the injury before the symptoms worsen.”
5. BluebirdBioby BluebirdZynteglo (beteggene autotemcel) – $2.8 million
Zynteglo is for beta thalassemia, a blood condition that usually requires regular blood transfusions.
“Prices for some prescription drugs and medicines will drop by almost 50-80-90%.”
“this Gene therapy “It helps patients make healthy red blood cells themselves, reducing the frequency of treatment needed,” Dubinsky said.
Top 5 Most Expensive Drugs by Sales Volume
John Stanford, executive director of Incubate, a Washington-based coalition of early-stage life science investors, shared his thoughts on the top five most expensive drugs in terms of sales volume.
“Usually, when the government focuses on the most expensive drugs, for example, it focuses on metrics based on sales volume, rather than rare disease therapy with high date prices but small patient pools,” he told Fox News Digital.
“In many cases, authorities focus on total drug spending through Medicare or other government programs.”

“When governments are usually focusing on the most expensive drugs, for example, they focus on metrics based on sales volume, rather than rare disease therapy, which is expensive but has a small pool of patients.” (istock)
1. Keytruda (Pembrolizumab) by Merck – $25 billion in revenue (2023)
Keytruda is an immunotherapeutic drug used in treatment Various cancersmelanoma, non-small cell lung cancer, liver cancer, etc.
“Keytruda became Merck’s Crown Jewel and helped expand our cancer treatment portfolio with over 1,000 active clinical trials,” Stanford told Fox News Digital.
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2. Eliquis (Apixaban) by BristolMyersSquibb and Pfizer – $189.5 billion
According to Stanford, elixis (apixaban) is an “anchor drug” for both BMS and Pfizer.
Apixaban is prescribed to prevent the formation of clots and to treat deep vein thrombosis and pulmonary embolism (pulmonary thrombosis).
3. Ozempic (Semaglutide) by Novo Nordisk – $139.3 billion
Prescription Type 2 diabetesSemaglutide drug therapy is widely popular for its weight loss benefits and other health benefits.

Ozempic, a semaglutide drug prescribed for type 2 diabetes, has become widely popular due to its weight loss benefits and other health benefits. (Reuters/Holly Adams/File Photo)
“Ozempic sales are driving a wide range of expansion into GLP-1 due to obesity. Heart disease Liver Conditions – all areas where development costs are high and scientific results are uncertain,” Stanford told Fox News Digital.
“Money depends on expanding production to meet GLP-1 demand and avoid supply shortages.”
4. Humira (Abbvie) – $14.4 billion (US revenues for 2023)
“Fumira is one of the most profitable drugs in history, generating more than $200 billion during its monopoly,” Stanford said.
Injections containing the active ingredient adalimumab are used in treatment Rheumatoid arthritis Other inflammatory conditions.
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5. Biktarvy by GILEAD – $11.85 billion
Biktarvy is an HIV treatment that contains three components: Bictegravir, Emtiticabine and Tenofovir Alafenamide.
“Biktarvy is not just a major thing HIV treatment -It’s the financial backbone for Gilead to move to cancer research,” Stanford said.
Which drugs may be affected?
Dr. Jacob Glanville, CEO of San Francisco biotechnology company Centivax, said vaccines and most generic drugs will not be changed by executive orders.
“Most vaccines that Americans take are under $100, and generic drugs often go under $1,” he told Fox News Digital.

“From a patient’s perspective, the prices of healthcare in the US are unsustainable, and some of them are very expensive drugs,” one expert said. “However, the insurance system and hospital business are also contributing.” (istock)
What Glanville is predicting is IP exclusiveness, antibody therapy, cell therapy, gene therapy, and new branded drugs still being personalized Cancer vaccine.
“Some of these are unbearably expensive. They range from $100,000 to $500,000 for a patient’s treatment course. But they often have a specific cancer, autoimmune disorder, or Rare illness. ”
Prices for innovation?
The pharmaceutical industry may argue that lowering prices for these drugs would result in a “dramatic investment” in creating such breakthroughs, Granville said.
Experts say the industry may also argue that these drugs will ultimately become common.
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“From a patient’s perspective, the price medical care “It’s unsustainable in the US and some of it is a very expensive drug,” he said. However, “the insurance system and hospital business are also contributing.”
“If the prices of new drugs are kept at the upper limit, we need to work to reduce the costs of clinical trials and drug GMP production, otherwise we will lose a lot of innovation.”
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Greg Norman of Fox News Digital Digital provided the report.