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Taking common over-the-counter painkillers can help you maintain Specific cancer From the spread.
This is a new study from the University of Cambridge found that aspirin can reduce cancer metastasis (diffusion) by stimulating participants’ immune systems.
The survey results were published in Nature on March 5th.
Aspirin may be associated with a lower risk of colorectal cancer, new research suggests
In a mouse model, scientists have discovered that a specific protein called ARHGEF1 suppresses T cells. It discovered that this is an immune cell that can identify and attack individual cancer cells that escape from the original tumor, according to a press release.
Taking common over-the-counter painkillers may help prevent certain cancers from spreading, new research suggests. (istock)
Arhgef1 is “on” when exposed to Thrombobsane A2 (TXA2), a chemical produced by platelets that helps blood clot. Too many TXA2s lead to higher risk Heart attack and strokes.
That’s where aspirin appears. It is already known to halt production of TXA2 and prevent coagulation, which is why it is recommended to prevent cardiac events in some people.
“Aspirin, or other drugs that may target this pathway, may be cheaper than antibody-based therapies.”
“This new study found that aspirin reduces TXA2 and releases T cells from suppression to prevent cancer from spreading,” the press release said.
With a mouse With melanomathose receiving aspirin had fewer cancer metastases than those without medication.
Daily aspirin after a heart attack can reduce the risk of future events, researchers say
“It was at the ‘Eureka’ moment that TXA2 was found to be a molecular signal that activates this inhibitory effect on T cells,” said Dr. Jie Yang, PhD, Faculty of Pathology, University of Cambridge, in the release.
“Above this, we had no realisation of the meaning of our findings in understanding the anti-metastatic activity of aspirin,” he continued.
“Aspirin, or other drugs that may target this route, could be cheaper Antibody-based therapiestherefore more globally accessible. ”
Aspirin can reduce cancer spreads by stimulating participants’ immune systems, studies have found. (istock)
Previous studies suggest that daily aspirin treatment is associated with reduced spread of cancer in humans with disease and lower cancer mortality in patients without metastasis, says Dr. Rahul Roychoudhuri, professor of cancer immunology at the University of Cambridge.
In one randomized controlled trial, 600 milligrams of aspirin were taken daily for an average of 25 months, significantly reducing the incidence of cancer in genetic carriers Colorectal cancer.
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Pashtoon Kasi, MD, medical director of gastrointestinal medical oncology in Hope Orange County, California, reiterated that previous studies have linked aspirin use to lower risk of cancer. Gastrointestinal tract cancer.
“It has been identified in a number of studies with complex consequences regarding reducing the risk of recurrence and/or improvement outcomes in patients with metastatic cancer,” Kasi, who was not involved in the study, told Fox News Digital.
“This new study further shows how to use aspirin and other inhibitors of this pathway in new therapies to prevent cancer metastasis and spread.”
Potential risks
Senior researcher Roychoudhuri called attention when applying the findings.
He said that aspirin is low-cost and widely available, but its long-term use lacks “significant risks.” senior citizen.
While aspirin is low-cost and widely available, its long-term use is not without “severe risks,” the researchers warned. (istock)
“This is why we emphasize that patients should not start taking aspirin to prevent cancer without specific medical advice from their doctor,” he said in a statement in Fox News Digital.
“Risk benefits calculations vary widely between individuals based on age, comorbidities and concurrent medication,” the doctor said. “Participant interested in aspirin therapy should discuss it with the oncologist, Family Practitionerwho can assess the potential benefits for risk. ”
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Kasi pointed to the potential limitation of this study, primarily that the study was conducted in mouse models rather than humans.
“The study also did not consider complications such as bleeding or interactions that people who use aspirin regularly experience. Other drugs” he pointed out.
Experts agree that patients should consult their physician to discuss the benefits and health risks associated with regular aspirin use. (istock)
“But it is based on a growing set of evidence… and provides mechanical insight into how this effect occurs from an immune perspective.”
Kasi agreed that patients would talk to their doctors to discuss the benefits and health risks associated with regular aspirin use.
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“In some cases, low-dose aspirin or other anti-inflammatory drugs have already been considered in clinical use and additional trials. For example, for individuals born with Lynch syndrome, who develop colorectal, endometrium and other cancers,” he says.
Next Steps
Scientists plan to conduct more research through ad-aspirin clinical trials recruiting more than 10,000 patients with early breasts, colorectal, gastroesophagus and gastroesophagus. Prostate cancer UK and across India – Determine if aspirin can stop or delay the recurrence of these cancers.
“Participant interested in aspirin therapy should discuss with an oncologist or family practitioner who can assess the potential benefits for risk.”
“Our Research suggests Aspirin may potentially be most beneficial for patients with early stage cancer who have been treated with therapeutic intent but may have irresistible micrometastases,” said Leuchouduri.
“However, further clinical verification is required before making any particular recommendations.”
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The study was funded by the Medical Research Council, the Welcome Trust and the European Research Council.
The Add-Aspirin clinical trial is funded by Cancer Research UK, National Institute of Health and Therapy, Medical Research Council and the TATA Memorial Foundation of India.
