compound found in marijuana Research published by the Hebrew University of Jerusalem could provide a new roadmap for treating the world’s most common chronic liver disorder.
The study, published in the British Journal of Pharmacology, found that cannabidiol (CBD) and cannabigerol (CBG) significantly reduced liver fat and improved metabolic health in experimental models.
CBD is the more widely studied non-intoxicating cannabinoid, while CBG is less common as the “precursor” cannabinoid from which CBD is formed.
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Unlike THC, the main psychoactive ingredient in cannabis, these compounds do not cause a “high,” making them good candidates for long-term use. medical careresearch suggests.
According to health data, metabolic dysfunction associated fatty liver disease (MASLD) currently affects approximately one-third of the world’s adult population.
The condition is closely linked to obesity and insulin resistance, and there are few approved drug treatments, forcing patients to rely primarily on drug treatment, the researchers said. Lifestyle changes That can be difficult to maintain.
“Our findings identify a novel mechanism by which CBD and CBG enhance liver energy and lysosomal function,” study lead author Joseph Tam, director of the Interdisciplinary Center for Cannabinoid Research at Hebrew University, said in a press release.
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The study focused on a process called “metabolic remodeling,” in which cannabis compounds created a “backup battery” for the liver by increasing levels of phosphocreatine, a high-energy molecule stored in the liver. muscle cells.
This energy reserve helps organs function under the stress of a high-fat diet, an unexpected finding, the researchers noted.
Researchers also found that CBD and CBG restore the activity of “cellular scavengers” known as cathepsins, enzymes that break down harmful fats and waste products in the recycling centers of cells.
Studies have shown that this process allows the liver to better remove dangerous lipids such as triglycerides and ceramides, which are known to cause inflammation.
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Both compounds were effective, but CBG showed stronger results in certain areas. total body fat amountlowers “bad” LDL cholesterol and improves insulin sensitivity.
Researchers say the study focuses on how cells manage energy and waste, opening new avenues for using plant-based compounds to treat metabolic diseases.
Despite the promising results, the research team cautioned that the study was conducted in a controlled experimental environment. Further clinical trials are needed to determine appropriate uses. human patient.
In other recent studies, potential problems Using cannabis as a medical tool.
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A major analysis published in JAMA examined more than 2,500 scientific papers from the past 15 years, including other reviews, clinical trials, and guidelines focused on medical cannabis.
A 2025 review highlighted large gaps between public perception and scientific evidence regarding the effectiveness of cannabis for most medical conditions.
Researchers conclude that there are few conditions for which cannabinoid therapy has clear, well-established effects backed by high-quality treatments. clinical data.
“Whenever a substance is used widely, there can be a very wide range of outcomes,” Dr. Alex Dimitriou, dual board certified in psychiatry and sleep medicine and founder of Menlo Park Psychiatry and Sleep Medicine, told Fox News Digital. “This study shows the reality that this widely used substance is not a panacea.”
The review provides the strongest evidence supporting the effectiveness of FDA-approved cannabinoid drugs in treating certain conditions, including HIV/AIDS-related anorexia, chemotherapy-induced nausea and vomiting, and certain severe childhood seizure disorders.
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Anyone interested in using marijuana for medical purposes should consult a professional. medical worker; medical institution Discuss potential risks and benefits.
