Among the surprising trends of Colorectal cancer cases New research rising among young people has identified potential sources.
Researchers at the University of California, San Diego have linked a bacterial toxin called colibactin to an increase in early onset cases.
According to the researchers, colibactin is produced by certain strains of E. coli (Escherichia coli) found in the colon and rectum.
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Exposure to bacterial toxins in early childhood can alter colonocyte DNA in ways that increase the risk of development Colorectal cancer Research was discovered before the age of 50.
In this study, the researchers analyzed 981 colorectal cancer genomes from early-onset and late-onset colorectal cancer patients in 11 countries. (istock)
The study, funded by Cancer Research UK, was published in the journal Nature on April 23rd.
“The key point is that exposure to colibactin is likely a major contributor to early-onset colorectal cancer,” Radmill Alexandrov, professor of bioengineering at Shu Chen Jane Ray, and professor of the School of Cell and Molecular Medicine in San Die, California, told Fox News Digital.
“They could be decades ahead of schedule to develop colorectal cancer.”
In this study, the researchers analyzed 981 colorectal cancer genomes from early-onset and late-onset colorectal cancer patients in 11 countries.
People who have been previously exposed to colibactin have found that there are specific mutations in the DNA, which are shown to occur primarily in. The first 10 years of life – “We will place children on an accelerated path to developing cancer as young adults.”
Research has found that exposure to bacterial toxins in early childhood can alter colon cells’ DNA in a way that increases the risk of developing colorectal cancer by the age of 50, studies have found. (istock)
The group was 3.3 times more likely to develop early-onset colorectal cancer than those diagnosed after age 70.
These mutations were found to account for 15% of early stages. Genetic changes This increases the risk of colorectal cancer.
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“We detected mutation signatures of colibactin in over 50% of colorectal tumors in patients under the age of 40, compared to less than 10% of tumors in older adults,” said Alexandrov.
“If someone acquires one of these driver mutations by the age of 10, it could be decades ahead of the expected development of colon cancer, and it could be at age 40 instead of 60,” says Alexandrov.
The fact that microbial exposure can leave behind a “permanent genome imprint” in the first few years of life is likely Contributes to cancer Researchers say that in adulthood he is “surprisingly calm.”
“There are a lot of other such exposures that we haven’t yet revealed, and it reminds us that the way we raise and protect children during these formative years can have long-term impacts on lifelong health,” he told Fox News Digital.
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“From my perspective, investing in childhood prevention, A healthy lifestyle And research is not merely important – it is essential. ”
Dr. Emil Lu, a board-certified oncologist and internal medicine physician at the University of Minnesota, agrees that the microbial flora – the “constellation of microorganisms containing bacteria that live under normal circumstances within our gut” is a potential perpetrator of early onset colorectal cancer.
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“Now is less surprising than it was 10 years ago Bacteria morphology – More specifically, toxins derived from bacteria may be associated with the main causes of cancer and potentially the main causes of cancer,” Lou, who was not involved in the study, told Fox News Digital.
“Of course of concern is the long-term period between exposure to bacteria early in life and the diagnosis of associated cancer.”
Potential limitations
Alexandrov noted that the study provides “strong genomic evidence” for a “salient association” between colibactin and early-onset colorectal cancer, but cannot prove a causal relationship.
“To demonstrate a clear causal relationship – to prove that colibuctin is sufficient to initiate cancer in humans remains an important challenge,” he told Fox News Digital.
Statistics show that in the past 20 years, adults under the age of 50 have doubled. (istock)
“The conclusive evidence of causality involves long-term prospective studies beginning in early childhood monitoring microbial colonization and tracking cancer incidence over decades.”
Lou agreed to this limitation and noted the complexity of cancer factors.
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“There are many aspects of our environment that can play a role in the development of cancer, both inside and outside our bodies,” he said. “It’s difficult to say, “A single factor given (in this case, whether a bacterial toxin is the true or even a major cause of colon cancer.”
“Providing evidence of potential relevance sets the foundation for more Detailed research To determine whether there is a true cause and effect, Lou added.
“If the current trend continues, colorectal cancer is predicted to be a leading cause of cancer-related deaths in young adults by 2030.”
Alexandrov said that while the findings still do not require changes to screening, Treatment Guidelinesthey emphasize the “important role of microbial exposure in childhood” in terms of long-term cancer risk.
“We are actively working to develop screening tests to detect the long-term effects of colibactin exposure, with the aim of translating these findings into actual prevention strategies in the near future,” he added.
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Statistics show that in the past 20 years, adults under the age of 50 have doubled.
“If the current trend continues, colorectal cancer is predicted to be the leading cause of cancer-related deaths in young adults by 2030,” the researchers concluded.
