Dental flossing can do more than ultimately improve oral hygiene.
New research led by Texas Institute of Technology and the University of North Carolina suggests that thin filaments ultimately include: Vaccine mechanism.
In animal models, researchers showed that dental floss can effectively release vaccines from tissues between teeth and gums, according to a press release.
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In this study, flossing technology caused the production of antibodies on the “mucosal surface.” Nose and lungsthe release said.
The findings were published in the journal Nature Biomedical Engineering.
“The mucosal surface is important because it is the source of invasion of pathogens such as influenza and covid,” said Harvinder Singh Gill, professor of chemistry and biomolecular engineering at North Carolina State University.
He noted that traditional methods of injecting vaccines produce antibodies primarily in the bloodstream.
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“But we know that when vaccines are administered through the mucosal surface, the antibodies are stimulated not only on the bloodstream but also on the mucosal surface,” Gill said.
“This will improve your body’s abilities Prevents infectionbecause there is an additional strain of antibody protection before pathogens enter the body. ”
The vaccine enters through the “junctional epithelium,” a thin layer of thin tissue in a deep pocket between the teeth and gums.
This organization does not have the same barriers as the inner layers of other organizations. This means that immune cells can be released into the body.
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In this study, researchers added a peptide influenza vaccine Dental floss without shaft Before flossing the teeth of the lab mouse, according to the release.
The efficacy of the floss placement vaccine was then compared to the techniques that supplied it nasally or verbally.
“When we applied the vaccine through the epithelium of the junction, we found that there was a much better antibody response on the mucus surface than the current gold standard for vaccinating the vaccine through the vaccine under the tongue. Texas Institute of Technology student.
“Floss technology also offers comparable protection Influenza virus Compared to vaccines administered via the nasal epithelium. ”
In addition to influenza, we repeated testing for three other vaccine types: protein, inactive virus, and mRNA.
For all types, floss techniques produced “robust antibody responses across the blood flow and mucosal surface,” says the release.
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Second, the research team aims to test the effectiveness of Vaccine delivery By using a flospick, it reaches the epithelial junction of humans.
“It’s easy to manage and many people are addressing concerns about getting the needle vaccinated,” Gill said. “And I think this technique should rival other vaccine delivery technologies and prices.”
Hua Wang, an assistant professor of materials science and engineering at the University of Illinois Grainger Engineering, was not involved in the study, but shared his response to the findings.
“This study presents a promising floss-based vaccination method that can avoid needle injections and potentially painful procedures,” he told Fox News Digital.
“The authors demonstrate that the vaccine component of floss-coated penetrates the epithelium of the junction of the gingival sulcus, reaching the underlying tissue, leading to a systemic antibody response.”
Floss-based vaccination methods may help improve patient compliance if patient compliance has passed. Complete evaluation processhe pointed out.
Researchers acknowledged that there are several limitations and drawbacks associated with floss-based vaccines.
For example, babies and toddlers who do not have teeth are not candidates for this technique.
“In addition, we need to know more about how or function this approach will work for people with periodontal disease or other oral infections,” Gill added.
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Wang agreed that many questions have not been answered about the method of vaccination of this experiment.
“In addition to the unclear effects of gingival tissue infection on vaccinations, the local and systemic side effects of this vaccination method are not yet understood,” he told Fox News Digital.
“For example, vaccination in gingival tissue can ultimately initiate local inflammation that induces unwanted side effects.”
Also, what exactly route does the vaccine component continue or how it continues as it moves from the tooth site to tissue. Immune response The king points out.
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“Finally, from a translation perspective, the effectiveness of floss-based vaccines must be comparable to traditional needle-based vaccines.”
The study was funded by the National Institutes of Health (NIH) and the Whaitakle Donation Chair of Science and Engineering at Texas Institute of Technology.
