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An experimental drug called Obicetrapib was undergoing a Phase 3 clinical trial at Monash University, Australia.
The trial included over 2,500 people with an average age of 65. According to a university press release, all of them were diagnosed with heart disease or had genetically high cholesterol.
This cheap pantry staple could be key to lowering cholesterol, a new study suggests
All participants received “maximum tolerance.” Cholesterol lowering therapy.
One group received obisetrapib and another took placebo while maintaining existing cholesterol medication.
New Daily Pills can provide an easier and more convenient way to lower cholesterol and reduce the risk of heart attacks and strokes. (istock)
After 12 weeks, participants will take it New drugs Showed a 32.6% reduction in LDL cholesterol and a 33.5% reduction in lipoprotein (A) [Lp(a)]the release said.
The findings were published last month at the UK’s European Atherosclerosis Association Conference and were also featured in the New England Journal of Medicine.
“We know that many people at high risk of heart attacks and strokes don’t even have the best available treatments to lower their cholesterol levels sufficiently,” says Stephen Nichols, director of Monash University’s Victorian Heart Institute and Monash Health’s Victorian Heart Hospital.
“Many people at high risk of heart attacks and strokes know that even the best available treatments don’t lower their cholesterol levels sufficiently.”
“Obicetrapib offers a promising new option. Not only did it lower LDL cholesterol by more than 30%, we also saw a decrease in LP(a). Risk of heart disease. ”
Low-density lipoproteins (LDLs), sometimes referred to as “bad cholesterol,” are associated with negative health effects when present in large quantities. (istock)
Low-density lipoproteins (LDLs), sometimes referred to as “bad cholesterol,” are associated with negative health effects when present in large quantities.
LDL can accumulate in blood vessels and increase the risk of heart attacks and stroke, researchers warned.
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Lipoprotein (A), or LP (A), is a protein known to significantly increase the chance of a heart attack when present at high levels in the blood.
Unlike LDL, LP(a) is a hereditary risk factor that cannot be altered by Healthy behavior Or medication.
Lipoprotein (A), or LP (A), is a protein known to significantly increase the chance of a heart attack when present at high levels in the blood. (istock)
Obicetrapib was found to be “well tolerated” by participants, researchers noted.
“This could be a valuable tool in the fight against heart disease,” Nichols added. “It may be convenient, effective and may help fill the gaps in patients who have no choice.”
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The study was funded by Newamsterdam Pharma, developer of Netherlands-based Obicetrapib, but there are some limitations, the researchers said.
Obicetrapib was found to be “well tolerated” by participants, researchers noted. (istock)
For example, participants were not selected based on high LP (a). In other words, this study did not determine how the drug affected people with increased protein levels.
Furthermore, this study assessed changes in LDL levels, but did not actually measure them. Heart attack or stroke result.
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More research The researchers acknowledged that it is necessary to follow patients for longer periods and include a more diverse cohort.
Fox News Digital has asked researchers for additional comment.
