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With the rise in cases of drug-induced liver damage (DILI), experts have warned of some commonly associated hidden dangers Medicines and supplements.
Statistics show that Dili, also known as toxic hepatitis or hepatotoxicity, is known to be a key cause of acute liver failure – has been growing in Western countries since the 1960s.
A recent survey published in the Journal Toxicology Reports shows that about a fifth of the total population, a prescribed drug, will experience DILI.
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Potential triggers for liver damage include herbal products, dietary supplements and drug therapy, research found.
Those with existing liver conditions Nutritional deficiency Like pregnant women, there is a higher risk.
With the increasing number of cases of drug-induced liver damage, experts have warned of hidden dangers associated with some common drugs and supplements. (istock)
How drugs can harm the liver
One of the main functions of the liver is to break down substances that have been ingested orally. Supplements and medicationsAccording to the American Gastroenterology (ACG).
For some people, the process of metabolizing these substances is slower and the risk of liver damage increases.
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The ACG says even drugs that have been tested for safety and approved by the US Food and Drug Administration (FDA) can potentially cause liver damage.
Common symptoms of liver disease include nausea, Loss of appetiteabdominal pain, generalized itching, dark urine and yellowing, but according to the above source, some people have no signs.
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The most common medicines that cause dili
A recent study in toxicology has identified several drugs that are most likely to cause liver damage.
- Paracetamol (acetaminophen), a common over-the-counter painkiller
- Nonsteroidal anti-inflammatory drugs (NSAIDs) that are commonly used to treat headaches, fevers and chronic inflammatory disorders
- Aspirin, a common over-the-counter drug used as a thermogenic reducing agent, Pain medicine The blood is thin
- Nimesulide, an NSAID used to relieve pain and reduce fever
- Methotrexate, an anti-metabolite drug used in treatment Rheumatoid arthritislymphoma, leukemia and other cancers
- Corticosteroids used to treat conditions that include inflammation or hyperactive immune systems
- Isoniazid, first-line treatment for tuberculosis
- Tetracycline, a class of antibiotics that treat multiple types Bacterial infection
- Halothane is used as a general anesthetic during surgical procedures
Turmeric, a common spice added to food, is associated with potential liver toxicity. (istock)
Supplements linked to liver damage
Drug therapy is not just drugs that can cause drug-induced liver damage.
Dr. Marc Siegel, Fox News Senior Medical Analystspoke with Fox News Digital about the risks of herbs and dietary supplements (HDS) that affect the liver.
“The biggest problem with herbal supplements is that the amount of active chemicals you are getting is not strictly regulated, so you don’t know exactly what you’re getting.”
“The biggest problem with herbal supplements is that you don’t know exactly what you’re getting because the amount of active chemicals you’re taking is not strictly regulated,” he said.
“And some supplements are metabolized through the liver, which increases the incidence of liver toxicity among users.”
A popular weight loss supplement, Garcinia Cambogia is one of the commonly used plant products known for its potential liver toxicity. (istock)
Dili cases linked to Herbs or dietary supplements According to a 2024 survey published on JAMA Network Open, it almost tripled between 2004 and 2014.
Researchers have identified the most commonly used plant products known for potential liver toxicity:
- Turmeric, common spices added to food
- Green Tea
- Ashwagandha, herbs used Stress and anxiety
- Garcinia Cambogia, Popular Weight Loss Supplements
- Red yeast rice. This is said to help lower cholesterol levels
- Black Cohosh, a dietary supplement used for mitigation Menopause symptoms
It is estimated that within the last 30 days at least 15.6 million US adults have used at least one of these six plant products.
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“The most commonly involved plant products in dillin (drug-induced liver damage network) include turmeric, kratom, green tea extracts and garcinia Cambodia, which lead to potentially severe and fatal liver damage,” the study states.
Drug-induced liver damage caused by HDS can be severe or even fatal, and can lead to death or liver transplantation, researchers noted.
Toxic hepatitis or hepatotoxicity – known to be a key cause of acute liver failure – has been growing in Western countries since the 1960s. (istock)
Siegel from Fox News also warned of the potential liver-related risks of some of these designated supplements.
“Turmeric is a natural anti-inflammatory agent and can be useful in small amounts, but can be toxic in large quantities,” he warned.
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“Garcinia Cambogia is very popular Weight loss agenthowever, there is no real evidence that it actually works, and there is no reason to take it, especially with the new GLP-1 drugs. ”
Red yeast rice has cholesterol-lowering statin-type properties, but Siegel warned that the amount of active chemicals is not as strictly regulated as approved drugs.
“Turmeric is a natural anti-inflammatory agent and can be useful in small amounts, but it is toxic at high doses.”
“I think it would be useful for some patients who are reluctant to start statins and are looking for a more natural alternative, but they need to closely monitor the amount taken and the effects on the liver,” he said.
Regarding Green TeaSiegel noted that it has antioxidant properties and can help it be consumed as a drink (although it has a lot of caffeine) – “But there is absolutely no reason to take it more with the extract.
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The FDA says on its website it regulates dietary supplements. Nutritionhowever, under “a different regulatory set from those that cover “traditional” foods and medicines.”
Drug-induced liver damage caused by HDS can be severe or even fatal and can lead to death or liver transplantation. (istock)
“Manufacturers and distributors of nutritional supplements and nutritional ingredients prohibit real estate or misbranded marketing products,” the agency says. “This means that these companies are responsible for assessing product safety and labeling prior to marketing, ensuring they meet all federal food, drug and cosmetic requirements as amended by DSHEA and FDA regulations.”
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Fox News Digital reached out Several researchers FDA for increased drug and HSD-related liver damage.
