Magnesium inhibits colorectal cancer carcinogenesis by increasing vitamin D-synthesizing bacteria

Researchers at Vanderbilt University Medical Center demonstrated on a precision basis Clinical trials Increases human intestinal bacteria that have been shown to be synthesized by magnesium supplements vitamin D and inhibit colorectal cancer Cancer.

However, the effect was observed primarily in women. The findings that researchers speculate may be attributed to the role estrogen plays in converting magnesium from circulation to cell absorption.

Intestinal microbiome data and colonoscopy results were analyzed from participants randomized by whether they had a TRPM7 genotype that plays an important role in magnesium regulation. calcium Acquire.

Previously, researchers showed in the same randomized trial that magnesium promotes vitamin D synthesis and increases blood concentrations of vitamin D. Findings from the current study suggest that magnesium does not pass to the blood and also increases the intestinal synthesis of vitamin D, which is locally effective.

These results of individual prevention of colorectal cancer trials are American Journal of Clinical Nutrition.

“Our previous studies have shown that magnesium supplementation increased blood levels of vitamin D when vitamin D levels are low,” says Dr. Qi Dai, a professor of medicine. “Current research reveals increased magnesium supplementation Intestinal microorganisms This has been shown to synthesize vitamin D in the intestines that are free from sunlight and locally inhibit the development of colorectal cancer. ”

Participants were divided into two arms. One received a magnesium supplement and the other received a placebo. Their gut microbiota were analyzed from stool, rectal swabs, and rectal tissue. Among participants with appropriate TRPM7 functions, magnesium supplements increased Carnobacterium maltaromatic and Faucaribacterium prausnitzii. Among those with inadequate TRPM7 function, magnesium supplements reduced the abundance of F. prausnitzii in the rectal mucosa.

Of the 236 participants with a history of colorectal polyps, 124 completed the trial with a median follow-up of 3.5 years, followed by 124 underwent colonoscopy. High abundance of F. prausnitzii in the rectal mucosa was associated with an almost three-fold increase in the development of additional polyps.

The findings suggest that magnesium Supplementary treatment may reduce the risk of colorectal cancer in individuals with insufficient TRPM7 function. Overall, these findings provide new insights into the interaction between nutrition and nutrition Intestinal microbiota It contributes to colorectal carcinogenesis and establishes the basis for a precision-based strategy for the prevention of colorectal cancer in high-risk populations.