Cannabis has been associated with some important medical benefits, but recent research has cast doubt on them.
A major new analysis published in JAMA examined more than 2,500 scientific papers from the past 15 years. This includes other reviews, clinical trials, and guidelines that focus on: medical cannabis.
“Many people are turning to cannabis for relief, but our study highlights a significant gap between public perception and scientific evidence about the effectiveness of cannabis for most medical conditions,” said study author Dr. Michael Hsu of UCLA Health Sciences in a press release.
researchers — Led by UCLA, with contributions from Harvard University, University of California, San Francisco, University of Washington School of Medicine, and New York University. — We set out to determine how strong the research on the effectiveness of medical cannabis is and provide evidence-based clinical guidance.
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The review found evidence to support most things. medical use The amount of cannabis or cannabinoids ingested is limited or insufficient, the release states.
According to the researchers, there are few conditions for which cannabinoid therapy has clear and well-established effects supported by high-quality clinical data.
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Strongest evidence supporting FDA-approved cannabinoid drugs to treat specific conditions such as HIV/AIDS-related anorexia, chemotherapy-induced nausea and vomiting, and certain serious conditions childhood seizure disorders.
For many other conditions commonly treated with cannabis, including chronic pain, insomnia, anxiety, and anxiety. post-traumatic stress disorder —Evidence from randomized trials did not support meaningful benefit.
The analysis also explored safety concerns, particularly how young people who use strong cannabis are more likely to suffer from psychotic and psychotic symptoms. anxiety disorder.
Daily inhaled cannabis use was also associated with an increased risk of coronary heart diseasereduced myocardial infarctions (heart attacks) and strokes when compared to casual use.
Based on these findings, this review highlights that clinicians need to weigh the potential benefits against the known risks when discussing cannabis with patients.
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The authors suggest that clinicians screen and assess patients for cardiovascular risk. mental health historyreview potential drug interactions and consider conditions where the risks may outweigh the benefits.
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They encourage open and realistic conversations and caution against assuming that cannabis has widespread effects on medical conditions.
“Patients should have honest conversations about what science is doing and not telling us about medical cannabis,” Hsu said.
This article is a narrative review, not a review. systematic reviewAs a result, the researchers noted that rigorous, standardized methods were not used to help reduce bias in study selection and evaluation methods.
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The review also pointed to further limitations, including that some of the evidence comes from observational studies rather than randomized trials, making it impossible to establish causality.
Additionally, study results may not apply to all populations, products, or doses.
