new Cancer Research Pioneered by Memorial Sloan Kettering points to powerful alternatives to chemotherapy, surgery, and radiation in several forms of cancer.
According to a new study published in the New England Journal of Medicine, nearly 80% of patients suffering from various cancer types were successfully treated with immunotherapy alone.
The immunotherapy protocol successfully treated 100% of patients with rectal cancer involved in the trial.
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“My husband, Tommy, and I were preparing for the worst,” recalls Maureen Sidelis, who was diagnosed with gastroesophageal junction cancer in 2022 and later became a participant in the trial.
Almost 80% of patients suffering from different cancer types were treated normally with immunotherapy alone, presupposed to the need for chemotherapy. (istock)
“After being treated with immunotherapy alone, I had no evidence of cancer and did not need surgery. Chemotherapy or radiation“She said in an MSK press release: “I felt like I had won the lottery!”
Gastrointestinal oncologist Dr. Andrea Cerseck oversaw the research along with fellow gastrointestinal oncologist Dr. Lewis Diaz.
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The pair, according to the release, sought to partially develop this approach due to the adverse effects of traditional treatments.
The immunotherapy protocol successfully treated 100% of patients with rectal cancer involved in the trial. (Aaron Chown/PA images via Getty Images)
“Using standard treatments such as surgery, radiation therapy and chemotherapy to treat rectal cancer is effective,” Cercek said.
“However, treatment leaves people infertile, and intestines, urine, and Sexual functionas well as other aspects of everyday life. ”
“After being treated with immunotherapy alone, I had no evidence of cancer and did not need surgery, chemotherapy or radiation.”
All participants in the study were patients with stage 1 to stage 3 tumors. This means that the tumor has not yet spread.
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Tumors also have genetic mutations called mismatch repair deficiencies (MMRDs), making them particularly vulnerable to the type of immunotherapy called “checkpoint inhibitors.”
Checkpoint inhibitors are delivered intravenously to participants, “masking” tumor cells, making it easier for the body to fight them. (istock)
The therapy “masks” tumor cells, MSK said, making it easier for the patient’s own immune system to recognize and kill cancer cells.
The first clinical trials of treatment all began with only 18 patients with rectal cancer.
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“I knew there was a wide range. Types of cancer It had the same MMRD genetic mutation, Cercek said. “We hoped that this approach would help people who are facing these other cancers as well.”
There were 49 patients in the expanded trial, which included 103 patients. Rectal cancer patients 54 patients with other types of cancer. Participants received checkpoint inhibitor infusions intravenously for six months per release.
Of the 54 patients with cancer other than rectal cancer, 35 patients had all signs of cancer disappearing after immunotherapy. (istock)
There was no evidence of cancer following immunotherapy in all 49 patients with rectal cancer.
Various tests performed for the study showed that out of 54 patients with other cancers, 35 had all signs of cancer disappeared after treatment.
“This was a very important response and the results were even better than we wanted,” Cercek said. “We found that several types of cancer responded very well to immunotherapy, including the colon. stomach cancer. ”
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Still in 20% of non-rectal cancer patients Necessary surgery After therapy, researchers saw that immunotherapy often shrinks tumors and further reduces several stages of tumors.
Dr. Timothy Yap, a medical oncologist at the University of Texas MD Anderson Cancer Center, agrees that the effectiveness of immunotherapy treatments against multiple types of cancer is “exciting.”
“Responding patients can avoid benefits by avoiding the need for surgery, chemotherapy and radiation therapy and improving quality of life,” said one oncologist. (istock)
“We are constantly looking to improve our innovative cancer patients’ treatment strategies. Clinical trialsand this is no exception,” Yap, who was not involved in the study, told Fox Digital.
“Responding patients can benefit from avoiding the need for surgery, chemotherapy, and radiation therapy and improving them. Quality of lifeHe said.
“This was a very important response and the outcome was even better than we wanted.”
Based on the results of the initial trial with rectal patients, the immunotherapy-only approach is incorporated into treatment guidelines from the National Cracerensive Cancer Network, a group of physicians setting up cancer treatments in the United States.
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Some of the first participants in the 2022 exam are still cancer-free for years after their initial treatment.
