Hidden genetic variation can predict male potential Onset of dementia.
That’s according to an Australian study led by Monash and Curtin University, which analyzed medical data from thousands of Australians and Americans.
The man who held it Specific Variants Hematopoietic (HFE) genes, which regulate iron levels in the body, have been found to be at a higher risk of dementia, researchers found.
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Healthy men over the age of 70 who have two copies of the variant known as H63D are at least twice as likely to develop dementia, or up to four times more.
Without just one copy it didn’t seem like the risk increased.
One in 36 carries two copies of the mutation. One in three people only have one copy.
“that’s right Only men Those who have two copies of the risky variant spoke to Professor John Olinik, a co-author at Curtin Medical School, to Fox News Digital. “Women are not affected by abnormalities.
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The study, published in the journal Neurology, used aspirin data to reduce events in the ASPREE trial, which collected 19,114 health and aging data. senior citizen.
People with genetic variants cannot change it, but Olynic pointed out that the “brain pathways” that affect them could be treated.
“The HFE gene is routinely tested in most Western countries. It is a disorder in which the body absorbs too much iron when evaluating people with hemochromatosis,” the doctor said. “Our findings suggest that this test could possibly be offered more widely to men.”
Despite the fact that the HFE gene is responsible for regulation Iron levelthe team found no direct link between iron and the risk of dementia.
“This refers to other mechanics during play, and probably includes an increased risk. Brain injury From inflammation in the body and cell damage,” Olynic added.
More research It is necessary to determine why women did not see an increased risk.
“Understanding why men with double H63D variants are at higher risk could pave the way for a more personalized approach Prevention and treatment“In a press release, Professor Paul Lakaz, co-author of Monash University, added.
According to Olynyk, the main limitation of this study was that the study population was composed primarily of Australians.
“It’s unclear whether other groups will have the same effect,” he told Fox News Digital. “To assess this, our work should be repeated in various countries.”
“More research will be done to determine the mechanisms that this abnormality can cause dementia and what can be done to reduce its effects.”
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Beyond this particular mutation, many other genetic and environmental factors may contribute to the risk of dementia, Olynyk noted.
“While we cannot change genetic risk factors, these mechanisms that cause genetic abnormalities and environmental factors can be corrected to some extent by adopting a healthy lifestyle and actively maintaining the overall good. Health statusHe said.
Researchers recommend hiring to reduce risk A healthy lifestyle This includes seeing a doctor to address medical issues known to exercise regularly, eat nutritious foods, minimize alcohol intake, remain mentally active, and increase the likelihood of dementia.
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The University of Melbourne, Royal Children’s Hospital, Murdoch Children’s Institute, and Fiona Stanley Hospital also contributed to this study.
