New drugs show promise by addressing treatment resistance Ovarian cancer.
Relacorilant, a drug tested in a phase 3 trial using California’s Corcept Therapeutics, was found to improve overall disease survival and progression when consistent with a chemotherapy drug called Nab-Paclitaxel.
According to a press release, the Rosella trial, conducted in collaboration with the GOG Foundation, analyzed 381 patients from around the world, including the US, Europe, South Korea, Brazil, Argentina, Canada and Australia.
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A large randomized, phase 3 trial found a 30% reduction in the risk of disease progression in patients with platinum-resistant ovarian cancer compared to those treated with NAB-paclitaxel. (Some types of chemotherapy include the elemental platinum.)
According to Corcept Therapeutics, patients whose disease has returned less than six months after receiving therapy containing platinum have a “platinum resistant” disease. (istock)
The researchers also noted this as a “significant improvement” to overall survival. Drug combinations.
Relacorilant, administered as an oral tablet, is reportedly “well tolerated” by patients without increasing side effects.
“It’s promising if the risk of recurrence is reduced by 30% and the risk of death is reduced by 31%.”
This drug is administered on the day of Nab-Paclitaxel therapy, administered via weekly infusion, and on the oral one day before the day.
The findings will be presented at a medical conference later this year, researchers say. Phase 2 results were published in the Journal of Clinical Oncology in 2023.
Ovarian cancer is the fifth most common cause Cancer death in women According to the Ovarian Cancer Research Union, it is the most deadly thing about gynecological cancer.
Alexander B. Olawaie, Director of Gynecology, Maryland Cancer research At the Magee-Women Hospital at the University of Pittsburgh, the Rosella trial principal investigator discussed the results on Fox News Digital.
Relacorilant, administered as an oral tablet, is reportedly “well tolerated” by patients without increasing side effects. (istock)
Olawaiye reiterated that the new agent was “the first of its kind” in the fight against cancer, which lacked many treatment options.
“That’s what really makes the findings of this study really exciting because it showed a huge improvement in progression-free survival and both survival and both. Overall survivalHe said.
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Experts shared their gratitude to his research team, saying that they “don’t stop trying” for the women I’m receiving treatment.
“I want to congratulate women who are being treated for ovarian cancer. First, and secondly, they helped me do this exam because there may be other options on the block.”
The researchers found that patients in the trial showed a 30% reduction in the risk of death. (istock)
Dr. Brianth Lomovitz, director of gynecological oncology for the Cancer Research Committee at Mount Sinai Medical Center in Miami Beach, Florida, also commented on these findings in an interview with Fox News Digital.
“Ovarian cancer has proven to be extremely difficult to treat, especially in patients with diseases that are resistant to standard chemotherapy,” he said.
“For a long time, we not only keep patients alienating illnesses for longer; I’ll live a long life. Unfortunately, most exams were negative. ”
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Slomovitz, a member of the Gog Foundation, said he views Roseella Trial as an “opportunity to use a unique drug” with “positive and encouraging results.”
“It is promising to reduce the risk of recurrence by 30% and the risk of death by 31%,” he said.
Relacorilant is given one day before, on the day of Nab-Paclitaxel chemotherapy, and one day after. This is administered via weekly infusion. (istock)
“Looking at data like this is refreshing and represents something exciting for patients suffering from ovarian cancer.”
Olawaiye shared his hopes for a treatment that would “quickly” clinical approval.
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As research and technology progresses, it varies. Cancer treatment It has emerged over the past few years.
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Olawaiye commented that the past 20 years have been “a very exciting time” due to the “explosion of approval” for cancer therapy.
“Today’s news about Relacorilant is just another addition,” he said.
