Obesity and stress can increase the risk of one of the most aggressive types of cancer, new research suggests.
Researchers at the University of California, Los Angeles (UCLA) found that stress-related neurotransmitters and obesity-related hormones activated CREB (cyclic AMP response element binding protein). Pancreatic cancer cells.
In this study, mice that ate a high-fat diet were more likely to develop pre-cancerous lesions. The lesions grew even further when stress levels were also increased due to social isolation.
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Stress-related cancer risk was more pronounced in female mice.
Based on these findings, researchers proposed to explore the use of Existing drugs To reduce the risk of obesity and stress-related cancers.
Obesity and stress can increase the risk of one of the most aggressive types of cancer, new research suggests. (istock)
“Beta-adrenergic receptors play an important role in stress-related conditions. Cancer growthcommonly used beta-blockers, drugs prescribed for hypertension, can be reused to alleviate these effects,” the press release states.
Pancreatic cancer is one of the most lethal types in the United States, with a five-year survival rate of just 13%.
One of the biggest challenges of the disease is that it is often detected during late stages when the disease is already progressing, according to Dr. Robert Den, a radiation oncologist, professor of radiation oncology and chief medical officer at Alpha Tau Medical in Israel.
“Unlike some other cancers, there are no effective early screening tools, so by the time a patient is diagnosed, treatment options are often limited,” Den, who was not involved in the study, told Fox News Digital.
“Unlike some other cancers, there are no effective early screening tools, so by the time a patient is diagnosed, treatment options are often limited.” (istock)
This study strengthens strong connections between Mind and body It is linked to cancer outbreaks, Den said.
“We know that stress and related pathways can exacerbate disease progression and that obesity can promote certain cancers and affect patients’ responses to treatment,” he said.
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“In this case, we see the evidence. Stress and obesity It may contribute to the worsening of pancreatic cancer, which has a significant impact on both preventive and therapeutic strategies. ”
Keep it A healthy heart diet And eating moderately is essential, Den noted – not just for cancer prevention, but for overall health.
Pancreatic cancer is one of the most lethal types in the United States, with a five-year survival rate of just 13%. (istock)
“Exercise is especially important in dealing with both obesity and stress,” he said. “Staying active is not only beneficial for your physical health, but it is also a great way to do it. Reduces stress. ”
Mindfulness can play an important role in reducing the risk of cancer, doctors advised.
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“Spending time outdoors can improve both mental and physical well-being, so I encourage patients to always be active, connect with nature, and find ways to prioritize. Overall wellnessHe said.
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Regarding Pancreatic cancer Treatment, Den noted that there have been some advances in chemotherapy and surgical techniques, but “there was no breakthrough yet.”
“Most immunotherapy that have been innovative with other cancers do not show the same promise for pancreatic cancer,” he said.
“Spending time outdoors can improve both mental and physical well-being, so I always encourage patients to be active, connect with nature, and find ways to prioritize overall health,” the oncologist said. (istock)
“The key challenge is finding ways to help patients who are not candidates for surgery, as surgery is the best line of defense.”
Fox News Digital has requested researchers for comment.
