Rock legend Ozzy Osbourne passed away on Tuesday at 76. Parkinson’s disease.
The lead singer of Black Sabbath has been open about his condition for the past few years, and first discussed it when he appeared on ABC’s “Good Morning America” in 2019.
He and his wife, Sharon Osborne, revealed Rockstar’s diagnosis In the case of PRKN-2, the genetic condition, usually defined as early-onset Parkinson’s disease, evolves more slowly.
“I’m not good at secrets,” the singer said. “I can’t walk around it anymore, because I seem to lack excuses. Do you know?”
Osbourne confirmed that there was a “bad fall” in the GMA, leading to neck surgery and interference with nerves.
Rocker took a little break from playing to handle his health complications, but only for a few weeks Before his deathhe finally made his way to the stage for Black Sabbath’s “Back to the Start” performance held in Birmingham, England on July 5th.
Developer Dr. Brandon Crawford Functional Neurosurgeon In Cedar Park, Texas, co-founders of the Austin Neurolysis Center said Parkinson’s disease could have a different effect on everyone.
Progressive neurodegenerative disorders affect areas of the brain called the midbrain, which produce chemical dopamine.
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Dopamine is known to promote happiness, but the body moves, thinks and thinks.
Crawford says that only about 10% to 15% of Parkinsonson cases are “clearly related” to genetics, but most are due to mild combinations. Genetic susceptibility Environmental triggers.
“It’s like a toxin, Head injurysleep disruption or chronic inflammation is balanced towards illness,” Crawford, who didn’t treat Osborne, told Fox News Digital.
People with Parkinson’s disease usually find themselves slowing down and unable to move. Some people experience trembling first, but Crawford is called a “characteristic sign” and often starts from the hand.
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This disease can also be caused Digestive complicationsconstipation, inflamed intestines, or general intestinal problems. Cognitive decline is also a “major component” in the development of Parkinson’s disease, doctors pointed out.
“Dopamine travels from the midbrain to the frontal lobe, which gives us the ability to think,” Crawford said. “It gives us a lot of executive skills, and our cognitive skills begin to decline.”
Patients may also notice sleeks and dysregulation moods, but often display them Signs of depression or a general lack of motivation.
“It’s not just trembling or slow moving,” Crawford said. “This neurodegenerative disease actually starts to affect someone else’s life.”
There is no cure for Parkinson’s disease, Dopamine agonists (dopamine mimics) and other stimulants that can stabilize symptoms for a limited time.
There could be a “moment of clarity” and a better move, Crawford said, “But when those drugs start to fade, everything will come back.”
Sharon Osborne explained her husband’s condition during an interview with GMA, explaining that “really bad days” often go on multiple occasions.
In 2024, the singer shared details alongside co-host Billy Morrison on an episode of his SiriusXM show “Ozzy Speaks.” Stem cell therapy Because of his condition, which he reportedly received for several years.
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Ozzy’s daughter, Kelly Osbourne, commented in a 2020 interview with UK-based stem cell bank Cell4Life, that her father’s progress after just one treatment was “surprising.”
“He wants to wake up. He wants to do things. He wants to be part of the world again,” she said. “He’s walking better. He’s talking better. His symptoms are decreasing. He’s regaining the strength of the muscle he needs.”
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According to General Brigham, stem cell therapy for Parkinson’s disease could replace dopamine neurons that have been lost to degeneration.
The Hospital System has announced FDA approval for the Phase 1 clinical trial for treatment in March.
According to Crawford, Ozzy Osbourne’s heavy metal rockstar lifestyle likely did not help his condition develop.
Circadian confusion can be a major precursor to Parkinson’s disease. With artificial lighting, you can wake up late at night and eat meals other than your usual schedule. Harm to the brain.
“When the sun sets, our retina, our brains, our whole biology is not designed to have this high-frequency light stimulation,” he told Fox News Digital. “Several studies have shown that this type of exposure can disrupt this circadian biology.”
These factors can also alter microbiota, intestinal function, neurotransmitter production, liver function, detoxification pathways, stem cell migration, and can also promote chronic inflammation, doctors warned.
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For people like Ozzy Osbourne, who lived a lifestyle that most likely didn’t consider “natural rhythms,” there could be a higher risk of other conditions. Like Alzheimer’s Experts say heart disease.
Other lifestyle factors that could lead to Osborne Parkinson’s diagnosis include the constant presence of loud music, substance abuse and bare heads, Crawford said.
“It’s going to create some repeated head trauma… If you’re there, if you’re going to constantly shake this brain in your head, like a bowl full of jelly,” he said.
Research shows that, in addition to loud music, long-term exposure to heavy metals in rock star environments such as mercury, manganese and lead can lead to an increased risk of Parkinson’s disease.
“When you’re traveling the world, you’re either staying in an old venue or using old equipment in poorly ventilated areas,” Crawford said. “All of these things start to add up.”
