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Home»Health»What to know about Cushing’s syndrome, which led to Amy Schumer's dramatic weight loss
Health

What to know about Cushing’s syndrome, which led to Amy Schumer's dramatic weight loss

u1news-staffBy u1news-staffDecember 13, 2025No Comments4 Mins Read
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comedian amy schumer44, recently opened up about her battle with Cushing’s syndrome, which led to her dramatic weight loss.

Schumer’s transformation became a hot topic online, and she responded to it with a now-deleted Instagram post, shutting down speculation about Schumer. Enhanced appearance.

“I didn’t lose 30 pounds. I lost 50 pounds,” she stressed on social media, adding that she hasn’t had Botox or fillers.

Amy Schumer loses 50 pounds to fight disease that could be ‘potentially fatal’ if left untreated

Schumer further emphasized that her weight loss What was important was not appearance, but staying alive.

“Don’t look too hot. I feel like it’s fun and temporary,” she said. “I did it to survive. I had a disease that caused my face to swell so badly that it killed me, but the internet caught on to it and the disease was cured.”

“I’m sorry for how losing weight made you feel,” she added. “I’ve had plastic surgery over the years, [Mounjaro]. I’m sorry to anyone I’ve disappointed. There is no pain. can [play] I teamed up with my son. ”

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The actress also addressed her own hormonal changes, saying, “If you have any questions about how I look or feel or how I am, I’d be happy to share more.” Perimenopausal process. ”

Schumer previously revealed that she had been diagnosed with the condition. cushing syndromea hormonal disorder that can cause extreme swelling, fatigue, and potentially fatal complications.

Dr. Peter Balazs, a New Jersey hormone and weight loss expert, expanded on this condition in an interview with Fox News Digital.

“Cushing’s syndrome is caused by long-term high exposure to cortisol, the body’s main stress hormone,” he says. “Excess cortisol is usually the result of long-term steroid use. We see this over and over again in patients with some type of autoimmune disease.”

Balazs said the “key” to Cushing’s syndrome is not simply: weight gainbut a “specific redistribution” of fat caused by excess cortisol.

The doctor said the fat is deposited on the abdomen, chest, upper back (known as the “buffalo hump”) and face, which is sometimes considered a “moon face.”

Cortisol also breaks down protein, which can cause your arms and legs to become thinner. “Weight gain can be exhausting, involuntary, and difficult to manage,” Balazs added.

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Doctors say cortisol stimulates the brain’s “hunger center,” raising blood sugar levels and promoting the accumulation of fat, especially deep fat in the abdominal region.

Cushing’s syndrome may also be a cause high blood pressureAccording to the Mayo Clinic, it can lead to bone loss and even type 2 diabetes.

In addition to weight gain in specific areas, symptoms include pink or purple stretch marks on the stomach, hips, thighs, breasts, and armpits, as well as acne, slow wound healing, and thin, easily damaged skin.

Women with Cushing’s syndrome often grow thick, black hair on their faces and bodies and experience irregular periods. Symptoms in men include decreased sexual desire, reduced fertility, and erectile dysfunction.

The Mayo Clinic listed other potential symptoms, including: extreme fatiguemuscle weakness, depression, anxiety, irritability, mood swings, decreased concentration and memory, headaches, insomnia, darkening of the skin, stunted growth in children.

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If you have symptoms, contact your doctor right away, especially if you have: taking steroids These drugs can make symptoms worse and are used to treat health problems such as asthma, arthritis, and inflammatory bowel disease.

The Mayo Clinic reports that “the sooner treatment begins, the greater the chance of recovery.”

For patients like Schumer, weight loss is not usually the main goal, but it is a “significant sign” of weight loss, Balazs said. treatment was successful.

“The main goal is to normalize high cortisol levels,” he says. “I think Amy Schumer was treated for the underlying problem first. Once her cortisol normalizes, which is the most important step, there is a role for using supplemental medications to help her lose weight.”

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Among GLP-1, Mounjaro “reduces deep abdominal fat; Increase insulin sensitivity number of cells,” Balazs added.

Fox News Digital’s Stephanie Giang-Paunon contributed to this report.

Fox News Digital has reached out to Schumer’s representatives for comment.

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